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Curcumin: It’s therapeutic benefits in chronic diseases and cancer.

September 21, 2025by Dt. Aarohi Andhare

Curcumin has shown therapeutic benefits in multiple chronic diseases and in several types of cancer. Since there is a relationship between inflammation and cancer, the anti-inflammatory properties of curcumin is the cause of its antitumor effect. Curcumin interferes with the cell signalling pathways and induces apoptosis and inhibits proliferation to modulate cancer progression. Research has been done to study the effects of curcumin as an anticancer agent in pancreatic cancer, colon cancer, colorectal cancer, multiple myeloma and oral cancer with positive findings. Curcumin has shown a significant antiproliferative effect against estrogen-dependent breast cancer cells. Curcumin’s antitumor activity on breast cancer, lung cancer, head and neck squamous cell carcinoma, prostate cancer, and brain tumors have been reported in many studies. Curcuminoids exert antioxidant activity mainly through the chelating effect of the diketone moiety in the presence of Cu, Fe, and Pb to boost the chelating power of curcumin derivatives. Despite the good prospect of curcumin in the management of cancer, its clinical development is affected by its low bioavailability and stability.

It is postulated that curcumin may interfere with some chemotherapy medications, but there are no studies supporting this claim. In one study 8 g/day curcumin was administered with gemcitabine found to be safe and well-tolerated in pancreatic cancer patients. Few adverse reactions were noted with use of higher doses of curcumin supplementation. Since most of the studies done on the safety and efficacy of curcumin were pre-clinical or pilot studies with small sample sizes, more well-powered clinical trials are needed to establish the safety and efficacy of anticancer benefits of curcumin.

At HealZen we have -Curcumin, a natural compound, exerts anticancer effects by inhibiting cancer cell proliferation and metastasis and by inducing cell cycle arrest and apoptosis. Curcumin exhibits potent inhibitory effects on breast cancer, the most prevalent type of cancer among women worldwide.
a. It has low maximal inhibitory concentration for breast cancer cell lines that express the hormone receptor ER and sensitizes cell lines to anticancer drugs. Moreover, it can induce apoptosis in cell lines independently of hormone receptor expression.
b. Curcumin resulted in a reduction in IκKβ activity in the salivary cells of HNSCC patients.
c. Curcumin has been reported to modulate growth factors, enzymes, transcription factors, kinase, inflammatory cytokines, and proapoptotic (by upregulation) and antiapoptotic (by downregulation) proteins. This polyphenol compound, alone or combined with other agents, could represent an effective drug for cancer therapy.
d. The observations made in this study suggest that curcumin does possess antitumor properties but, unlike other known chemotherapeutic compounds, curcumin does not cause any damage to the normal cells. To boost curcumin absorption, Add black pepper, healthy fats such as coconut oil, ghee, olive oil, nuts in your daily diet.

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